Physicians really love “blind studies” where one group of individuals is given a particular medication while another group is given placebos (e.g., a ‘dummy’ pill). Now here comes a study that even lawyers might appreciate:

In an Associated Press, July 5, 2006, story it seems that healthy adults, who were given maximum doses of Tylenol for two weeks had abnormal liver test results, raising concerns that even recommended amounts of the popular painkiller might lead to liver damage.

In the study, 106 participants took four grams of Tylenol — equivalent to eight extra-strength Tylenol tablets — each day for two weeks. Some took Tylenol alone and some took it with an opioid painkiller. Dummy pills were given to 39 others.

There were no alarming liver test results among the people who took the placebos. But nearly 40 percent of people in all the other groups had abnormal test results that would signal liver damage, according to the study that appeared recently in the Journal of the American Medical Association.

One of the study co-authors, Dr. Neil Kaplowitz, of the University of Southern California said "I would urge the public not to exceed four grams a day. This is a drug that has a rather narrow safety window." And Kaplowitz added that heavy drinkers should take no more than two grams daily.

Another co-author, Dr. Paul Watkins of the University of North Carolina, said he’s less worried than Kaplowitz, noting that acetaminophen, the active ingredient in Tylenol, has been used for 50 years and has a good safety record.

The maker of Tylenol, McNeil Consumer & Specialty Pharmaceuticals, said its own research found much lower rates of abnormal liver results. The company’s studies tracked high-dose users over longer periods than did the new study.

The researchers had been hired by the drug company Purdue Pharma LP, maker of the prescription painkiller OxyContin, to find out why abnormal liver tests were showing up in people testing a combination drug containing the acetaminophen and the opiate hydrocodone.

Purdue Pharma stopped its hydrocodone study early because of the abnormal liver tests. Researchers Watkins and Kaplowitz thought they would find the culprit in hydrocodone’s interaction with acetaminophen.

"Our jaws dropped when we got the data," Watkins said. "It doesn’t have anything to do with the opiate. It’s good ol’, garden-variety acetaminophen."

Acetaminophen is more popular than aspirin or ibuprofen. Each week, one in five U.S. adults uses it for pain or fever, a 2002 survey found.

Acetaminophen is included in numerous over-the-counter and prescription medications, making overdose possible as people unwittingly combine drugs. Overdoses of acetaminophen are the leading cause of acute liver failure.

New research under way at the University of North Carolina may determine if acetaminophen’s effect on the liver continues for long-term, high-dose users, or if the body adapts, Watkins said.

About The Author:
Attorney Edward A. ("Ted") Bills can be reached at 719.444.1000 or at http://www.SpringsAttorney.com.

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